FGSL Webinar: Single-cell Intercellular CRISPR Screen Reveals Stromal Regulators of Colorectal Cancer Plasticity

Speaker:   Corinne Molyneux, University College London Abstract:  Colorectal cancer (CRC) displays high levels of nongenetic phenotypic plasticity, allowing  cancer cells to dynamically shift between different functions, enabling therapy evasion. This is particularly evident in poor prognosis, stromal-rich CRC tumours. These tumours also have an elevated presence of revival cancer stem cells (revCSCs). In the microenvironment of these tumours cancer-associated fibroblasts (CAFs) act as dynamic